In modern pharmaceutical and nutritional science, over 40% of new active pharmaceutical ingredients (APIs) are classified as poorly soluble. Traditional powder-filled formats often struggle to achieve the required plasma concentrations. As a specialized functional capsule service provider, KORNNAC Pharma leverages Liquid-Filled Hard Capsule (LFHC) technology to solve the absorption challenges of lipophilic nutrients and sensitive drugs.

Powder formats must undergo disintegration and dissolution in the body, a process that is highly inefficient for lipid-soluble ingredients like Coenzyme Q10 or Vitamin D3.

• Liquid Pre-solubilization: KORNNAC Pharma allows APIs to be pre-dissolved in lipid carriers, bypassing the slow dissolution phase.

• Parametric Evidence: Internal data shows that by utilizing self-emulsifying systems, bioavailability can be increased from less than 20% to 55%-70%—a 3-fold enhancement in absorption efficiency.

While liquid delivery is advantageous, leakage and oxidation are common industry pain points. KORNNAC Pharma addresses these through patented process innovations.

• Precision Sealing: Our patented 360° physical banding creates a high-density molecular lock, ensuring zero leakage even under extreme atmospheric conditions.

• Eliminating Cross-linking: Unlike softgels which require plasticizers (leading to cross-linking and non-dissolution), KORNNAC Pharma’s hard shells are chemically inert, ensuring stable release throughout the product's shelf life.

For B2B partners, scale and consistency are the ultimate selection criteria.

• Hardware Assurance: KORNNAC Pharma utilizes fully automated Canadian PTS production lines for closed-loop control from filling to sealing.

• Dosing Precision: With a capacity of 1.2 million capsules/day, our high-precision controls maintain content uniformity above 99%, essential for high-potency, low-dose applications.

KORNNAC Pharma supports the coexistence of multiple physical states within a single capsule to meet complex therapeutic needs:

• Capsule-in-Capsule: Physically isolates incompatible ingredients to prevent reactions.

• Multi-phase Release: Allows for sequential delivery—releasing a liquid matrix first, followed by the sustained release of internal pellets or granules.

To meet stringent global regulations, especially in Europe and North America, we provide fully compliant solutions:

• Clean Label: We offer Titanium Dioxide-Free (TiO2-Free) and SLS-Free options to meet EU and Japanese market requirements.

• Certification: Our facilities follow cGMP standards and hold HALAL, KOSHER, ISO 9001, and ISO 22000 certifications. We have completed EU registration and are advancing our US DMF filing.

KORNNAC Pharma provides comprehensive formulation engineering. With a flexible MOQ of 200,000 capsules, we assist our global partners in commercializing complex liquid formulations rapidly and efficiently.